Antigen presenting cells (APCs) of the immune system, such as dendritic cells, can stimulate naïve CD8+ effector T cells to identify and destroy tumors. Given this tremendous anti-tumor potential, there is great interest in harnessing the power of APCs for cancer immunotherapy. APC-based cancer therapies are considered vaccines in that they provoke the patient’s immune system to kill the tumor. However, efforts to develop APC-based cancer vaccines have produced limited success, partially due to suppression of APC function by the tumor environment. A research team at Baylor Scott & White Research Institute (BSWRI) examined a strategy to overcome these challenges by designing cancer vaccines from artificial APCs (aAPCs).